"Noddy" <me@[EMAIL PROTECTED]
> wrote in message
news:482bc71a$0$58061$c30e37c6@[EMAIL PROTECTED]
>
> "John McKenzie" <jmac_melbourne@[EMAIL PROTECTED]
> wrote in message
> news:482BC097.6EE8@[EMAIL PROTECTED]
>
> > Jesus Christ - I know there's some margin of safety engineered into
max
> > dosages (8 per day if anyone cares) - but at 20 - you seriously are
> > risking death - and it could be severe enough to have rebound and
> > complications (within hours of taking them) that mimic high blood
> > pressure, and angina, and prevent sleep etc.
>
> Yeah, I've got most of those, and liver counts 6 times higher than the
> accepted norm.
>
> > It's probably more the paracetemol imho. ****ing hell - can't you get
> > them to prescribe oxycontin or percocent or whatever they are called
> > here - they use oxycodone, which is far more effective (at lower
doses,
> > and as such with lower concomitant amounts of paracetemol) than
codeine
> > ever could be. The problem with codeine, aside from that mentioned, is
> > it has to be converted (I think in the liver but can't recall) into
> > something else - some other type of opiate. In typical subjects,
there's
> > only enough enzyme or whatever to convert around 400mg tops in one go,
> > or possibly one day, so beyond that, you aren't going to gain much
> > anyway, you'll just think you are.
>
> Oh yeah, there's a placebo effect associated with it, which is why I'm
now
> back down to 8-10 a day rather than 20.
>
> > In that situation, I'd definitely be looking at the oxycontin or
> > whatever the equiv is. With your chronic injury, and ongoing
> > complications from the ****ed up hip surgery (if I recall correctly)
> > you'd surely qualify.
>
> I'll talk to my quack about it.
>
> Last time I spoke to him he mentioned herbal jazz cigarettes (medically
> prescribed) might be worth a shot as I'm already a smoker, and while I
> thought about it for a while I decided against it as I never liked
cannabis
> and whenever I experimented with it socially all it did was gave me a
> whacking great headache. I also didn't like the idea of walking around
> ripped all day and then trying to do anything constructive as I have
enough
> trouble now just getting zonked on the pain killers.
>
> Still, I could always get a kilo a week and sell it :)
If you have periods where your pain is beyond the relievers you now use,
and
codeine is a good PK for mild to moderate pain, you need an appraisel by a
pain clinic. These places are only really interested in devices (external
and internal nerve stimulators) and injections of anaesthesia at or near
the
painful site. Beyond that they give up and may recommend Oxycodone in SR
form (2 tabs a day with an extra for "breakthru pain"). Morphine has
fallen
from grace even in SR form (MSContin) according to nursing staff at the
Sydney hosp I was at last year,.."it's too addictive". They prefer to use
Fentanyl or OxyContin a slow release (1 twice a day) big hitter. If you
are
having trouble, it's a long journey to get proper relief,
unfortunately,..unless half your head is split open or you have cancer.
Jason
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